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Literature summary for 3.4.21.108 extracted from
- Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils (2004), Cell Death Differ., 11, 937-939.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ucf-101 | 0.02 mM abrogates the death effect of the TNF-alpha + zVAD combination | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | HtrA2 relocates to the cytoplasm upon apoptosis | Homo sapiens | 5737 | - |
| mitochondrion | normally expression of HtrA2, enzyme does not leave the mitochondria upon the TNF-alpha + zVAD-induced cell death in neutrophils | Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | from the peripheral blood of healthy donors | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| X-linked inhibitor of apoptosis protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Omi/HtrA2 | - |
Homo sapiens |
| serine protease | - |
Homo sapiens |
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