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Literature summary for 3.4.21.108 extracted from
- Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease (2004), Biochem. J., 381, 895-904.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli BL21 (DE3) | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| with Ni-NTA-agarose column | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
peptide derived from type III collagen alpha1 C-propeptide does not activate nor significantly bind to HtrA2 as compared to HtrA1 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| reduced bovine serum albumin | HtrA2-Opt peptides stimulate the delta N-HtrA1 protease activity more than 3fold | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high temperature requirement A serine protease | - |
Homo sapiens |
| HtrA2/Omi | - |
Homo sapiens |
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