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Literature summary for 3.4.21.108 extracted from

  • Cilenti, L.; Lee, Y.; Hess, S.; Srinivasula, S.; Park, K.M.; Junqueira, D.; Davis, H.; Bonventre, J.V.; Alnemri, E.S.; Zervos, A.S.
    Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2 (2003), J. Biol. Chem., 278, 11489-11494.
    View publication on PubMed
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mammalia

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 78% inhibition at 0.02 mM, complete inhibition at 0.08 mM Mammalia
ucf-102 inhibits, but to a lesser extent than ucf-101 Mammalia
ucf-103 inhibits, but to a lesser extent than ucf-101 Mammalia
ucf-104 58% inhibition at 0.02 mM Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mammalia 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia induces cell death in a caspase-dependent manner ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-casein + H2O
-
 Mammalia ?
-
 ?
beta-casein + H2O
-
 Mammalia ?
-
 ?
dephosphorylated casein + H2O
-
 Mammalia ?
-
 ?
additional information induces cell death in a caspase-dependent manner Mammalia ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA2/Omi
-
 Mammalia
S01.278 Merops ID Mammalia