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Literature summary for 3.4.21.108 extracted from

  • Verhagen, A.M.; Silke, J.; Ekert, P.G.; Pakusch, M.; Kaufmann, H.; Connolly, L.M.; Day, C.L.; Tikoo, A.; Burke, R.; Wrobel, C.; Moritz, R.L.; Simpson, R.J.; Vaux, D.L.
    HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins (2002), J. Biol. Chem., 277, 445-454.
    View publication on PubMed
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mammalia

Protein Variants

Protein Variants Comment Organism
A144G mutation reduces ability to promote cell death, weak interaction with XIAP Mammalia
A147I increased affinity for the BIR3 domain of XIAP Mammalia
S306A mutation reduces ability to promote cell death Mammalia
S306A/A144G complete loss of proapoptotic activity Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mammalia 16020
-
mitochondrion in response to UV irradiation the enzyme shifts into the cytosol Mammalia 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 calculated from nucleotide sequence Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification precursor protein is processed to yield an active protase Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
 Mammalia ?
-
 ?
additional information role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs Mammalia ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA2/Omi
-
 Mammalia

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mammalia

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mammalia

pI Value

Organism Comment pI Value Maximum pI Value
Mammalia calculated from nucleotide sequence
-
 6.7