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Literature summary for 3.4.21.108 extracted from
- Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response (2000), Eur. J. Biochem., 267, 5699-5710.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S306A | mutant with abolished autoproteolysis | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| enzyme undergoes autoproteolysis | Mus musculus |
| enzyme undergoes autoproteolysis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | complete inhibition at 4 mM | Homo sapiens |  |
| N-tosyllysine chloromethyl ketone | 51% inhibition at 5 mM | Homo sapiens | |
| phenylmethanesulfonyl fluoride | 51% inhibition at 5 mM | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | role in apoptosis | ? | - |
? | |
| additional information | Homo sapiens | role in apoptosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43464 | - |
- |
| Mus musculus | Q9JIY5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-casein + H2O | - |
Mus musculus | ? | - |
? | |
| beta-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | role in apoptosis | Mus musculus | ? | - |
? | |
| additional information | role in apoptosis | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HtrA2 | - |
Mus musculus |
| HtrA2 | - |
Homo sapiens |
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Release 2026.1 (March 2026)
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