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Literature summary for 3.4.21.108 extracted from
- Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis (2022), Hum. Cell, 35, 63-82.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uncoupling protein 2 + H2O | Mus musculus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uncoupling protein 2 + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high-temperature requirement A2 | - |
Mus musculus |
| HtrA2 | - |
Mus musculus |
| HtrA2/Omi | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | decreased enzyme function damages mitochondrial quality in the heterozygous mouse brain cortex, leading to more brain ischemia/reperfusion injury. HtrA2-heterozygous mice show decreased mitochondrial quality control and reduced mitochondrial function after ischemia/reperfusion injury, decreased anti-damage ability and increased apoptosis after middle cerebral artery occlusion | Mus musculus |
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