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Literature summary for 3.4.21.104 extracted from

  • Boldt, A.B.; Beltrame, M.H.; Catarino, S.J.; Meissner, C.G.; Tizzot, R.; Messias-Reason, I.J.
    A dual role for Mannan-binding lectin-associated serine protease 2 (MASP-2) in HIV infection (2016), Mol. Immunol., 78, 48-56 .
    View publication on PubMed
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Application

Application Comment Organism
medicine evaluation of the role of MASP-2 in HIV infection. The MASP-2 .126L variant is associated with MASP-2 levels <200 ng/ml and increases the susceptibility to HIV infection and to HIV plus hepatitis B virus positive status. p.126L in addition to other variants associated with low MASP-2 levels such as p.120G, p.377A and p.439H, presents a protective effect against AIDS, independently of age, sex, hepatic function andviral load. MASP-2 serum levels are lower in HIV positive and HIV plus hepatitis B virus positive patients than in controls. Among patients, MASP-2 levels are higher in patients with opportunistic diseases and AIDS. MASP-2 levels correlate positively with MBL/MASP2-mediated complement component C4 and negatively with CD4+ cell counts Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00187
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