Literature summary for 3.4.21.104 extracted from

Yaseen, S.; Demopulos, G.; Dudler, T.; Yabuki, M.; Wood, C.L.; Cummings, W.J.; Tjoelker, L.W.; Fujita, T.; Sacks, S.; Garred, P.; Andrew, P.; Sim, R.B.; Lachmann, P.J.; Wallis, R.; Lynch, N.; Schwaeble, W.J.
Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2 (2017), FASEB J., 31, 2210-2219 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00187	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
complement component C3 + H2O	-	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	under physiologic conditions lectin pathway-specific complement component C4 and/or C2 bypass activation of C3 is mediated by direct cleavage of native C3 by mannan-binding lectin-associated serine protease-2 bound to lectin pathway-activation complexes captured on ligand-coated surfaces	Homo sapiens

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Release 2023.1 (January 2023)