Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.104 extracted from

  • Degn, S.E.; Jensen, L.; Olszowski, T.; Jensenius, J.C.; Thiel, S.
    Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44 (2013), J. Immunol., 191, 1334-1345.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293F FreeStyle cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00187
-
-

General Information

General Information Comment Organism
physiological function the addition of mannan-binding lectin or ficolins allows the formation of serine proteases MASP-1-MASP-2 co-complexes. Such co-complexes have a functional role in activating complement and are present in serum at varying levels, impacting on the degree of complement activation. MASP-2 can be found in complex with each of the other MASPs and mannan-binding lectin-associated proteins in serum, and coexpression of MASP-2 with MASP-1, MASP-3, or mannan-binding lectin-associated protein 4 leads to detectable levels of heterodimers Homo sapiens