Cloned (Comment) | Organism |
---|---|
expression in HEK-293F FreeStyle cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00187 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | the addition of mannan-binding lectin or ficolins allows the formation of serine proteases MASP-1-MASP-2 co-complexes. Such co-complexes have a functional role in activating complement and are present in serum at varying levels, impacting on the degree of complement activation. MASP-2 can be found in complex with each of the other MASPs and mannan-binding lectin-associated proteins in serum, and coexpression of MASP-2 with MASP-1, MASP-3, or mannan-binding lectin-associated protein 4 leads to detectable levels of heterodimers | Homo sapiens |