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Literature summary for 3.4.21.104 extracted from

  • Asgari, E.; Farrar, C.; Lynch, N.; Ali, Y.; Roscher, S.; Stover, C.; Zhou, W.; Schwaeble, W.; Sacks, S.
    Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4 (2014), FASEB J., 28, 3996-4003.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q91WP0
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-

Synonyms

Synonyms Comment Organism
MASP2
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Mus musculus

General Information

General Information Comment Organism
physiological function effect of MASP-2 deficiency in an isogenic mouse model of renal transplantation. Wild-type kidneys grafted into wild-type recipients develop acute renal failure. Wild-type grafts transplanted into MASP-2-deficient recipients show significantly better kidney function, less C3 deposition, and less ischemia reperfusion injury. In the absence of donor or recipient complement C4, the wild-type to wild-type phenotype is preserved, indicating that the MASP-2-mediated damage is independent of C4 activation. In mice deficient for both MASP-2 and C4, the protection from postoperative acute renal failure is no greater than in mice with MASP-2 deficiency alone. Injury occurs through MASP-2-dependent activation events independent of C4 Mus musculus