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Literature summary for 3.4.21.104 extracted from
- Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi (2009), Mol. Immunol., 47, 426-437.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the complement C2 receptor inhibitor trispanning protein extracellular domain 1 inhibits MASP2 cleavage of C2 complement factor, the addition of 0.0015 mM of ed1 peptide, a 3fold molar excess over C2, completely inhibits C2 cleavage by recombinant MASP2 | Trypanosoma cruzi |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C2 + H2O | Trypanosoma cruzi | - |
complement component C2b + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epimastigote | - |
Trypanosoma cruzi | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C2 + H2O | - |
Trypanosoma cruzi | complement component C2b + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MASP2 | - |
Trypanosoma cruzi |
| MBL-associated serine protease 2 | - |
Trypanosoma cruzi |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | lectin pathway activation by Trypanosoma cruzi requires the MASP2 activity resulting in C2 complement factor cleavage | Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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