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Literature summary for 3.4.21.104 extracted from

  • Venkatraman Girija, U.; Furze, C.; Toth, J.; Schwaeble, W.J.; Mitchell, D.A.; Keeble, A.H.; Wallis, R.
    Engineering novel complement activity into a pulmonary surfactant protein (2010), J. Biol. Chem., 285, 10546-10552.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ficolin
-
Rattus norvegicus
mannose-binding lectin
-
Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Chinese hamster ovary cells, recombinant wild type rat MASP-2 is toxic to producing Chinese hamster ovary cells and autoactivates during biosynthesis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-Sepharose column chromatography Rattus norvegicus

Synonyms

Synonyms Comment Organism
MASP-2
-
Rattus norvegicus
MASP-2A catalytically inactive form in which the active site serine at position 613 has been replaced by alanine Rattus norvegicus
MASP-2K catalytically active form in which the arginine residue at the cleavage site for zymogen activation (Arg424) has been changed to a lysine residue to slow down the rate of spontaneous autoactivation during biosynthesis Rattus norvegicus
MBL-associated serine protease-2
-
Rattus norvegicus