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Literature summary for 3.4.21.104 extracted from

  • Krarup, A.; Wallis, R.; Presanis, J.S.; Gal, P.; Sim, R.B.
    Simultaneous activation of complement and coagulation by MBL-associated serine protease 2 (2007), PLoS ONE, 2, e623.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.104

Cloned(Commentary)

Cloned (Comment) Organism
expression of mutant enzyme R424K in CHO cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information construction of a truncated active enzyme form Rattus norvegicus
R424K site-directed mutagenesis, mutation at the zymogen cleavage site, yielding an active form of MASP2 that is secreted as zymogen but is more stable than wild-type MASP2, since it only autoactivates in complex with MBL upon binding to a suitable surface Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C2 + H2O Rattus norvegicus
-
 ?
-
 ?
complement component C4 + H2O Rattus norvegicus
-
 ?
-
 ?
additional information Rattus norvegicus the enzyme is part of the lectin pathway of the complement system, it is also capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin ?
-
 ?
plasminogen + H2O Rattus norvegicus activation plasmin + propeptide of thrombin
-
 ?
prekallikrein + H2O Rattus norvegicus activation kallikrein + propeptide of thrombin
-
 ?
prothrombin + H2O Rattus norvegicus activation of thrombin covalentyl bound to a bacterial cell surface thrombin + propeptide of thrombin
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
 Rattus norvegicus ?
-
 ?
complement component C4 + H2O
-
 Rattus norvegicus ?
-
 ?
additional information the enzyme is part of the lectin pathway of the complement system, it is also capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin Rattus norvegicus ?
-
 ?
additional information MASP2 acts in a mannan-bound MBL/MASP2 complex Rattus norvegicus ?
-
 ?
Phe-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus ?
-
 ?
plasminogen + H2O
-
 Rattus norvegicus plasmin + propeptide of thrombin
-
 ?
plasminogen + H2O activation Rattus norvegicus plasmin + propeptide of thrombin
-
 ?
prekallikrein + H2O
-
 Rattus norvegicus kallikrein + propeptide of thrombin
-
 ?
prekallikrein + H2O activation Rattus norvegicus kallikrein + propeptide of thrombin
-
 ?
prothrombin + H2O activation of thrombin covalentyl bound to a bacterial cell surface Rattus norvegicus thrombin + propeptide of thrombin
-
 ?
prothrombin + H2O cleavage scheme, overview Rattus norvegicus thrombin + propeptide of thrombin
-
 ?
Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
MASP2
-
 Rattus norvegicus
MBL-associated serine protease 2
-
 Rattus norvegicus