Activating Compound | Comment | Organism | Structure |
---|---|---|---|
mannan-binding lectin | MBL, binds and activates MASP-2 by increasing the rate of autocatalysis when it binds to an activating surface, interaction of MASP-2 with mannan-binding lectin is Ca2+-dependent, activation mechanism, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | interaction of MASP-2 with mannan-binding lectin is Ca2+-dependent, the Ca2+-binding site is located in the CUB1 module, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the lectin pathway of complement plays a key role in the immune system by recognising pathogens through patterns of sugar moities displayed on their cell sufaces and neutralizing them in an antibody-independent reaction cascade, MASP-2 binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, interactions analysis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the lectin pathway of complement plays a key role in the immune system by recognising pathogens through patterns of sugar moities displayed on their cell sufaces and neutralizing them in an antibody-independent reaction cascade, MASP-2 binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, interactions analysis, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme performs proteolytic autoactivation, mannan-binding lectin, MBL, structure and Ca2+-dependent interaction with the enzyme, overview, MAp19 is a product of alternative splicing of the MASP-2 gene and is catalytically inactive, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | domain organizations of MASP-2 and mannan-binding lectin, MBL, overview, the N-terminal third of MASP-2, i.e. MAp19 or sMAp, comprises the CUB1 and EGF modules of MASP-2 plus an extra C-terminal EQSL tetrapeptide, which is encoded by a separate exon, overview, enzyme structure and domain organization: CUB1 module, EGF module, CUB2 module, CCP1, CCP2, and serine protease domains, the very flexible C-terminal catalytic SP region, active site structure, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MASP-2 | - |
Homo sapiens |