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Literature summary for 3.4.21.104 extracted from

  • Wallis, R.
    Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway (2007), Immunobiology, 212, 289-299.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
mannan-binding lectin MBL, binds and activates MASP-2 by increasing the rate of autocatalysis when it binds to an activating surface, interaction of MASP-2 with mannan-binding lectin is Ca2+-dependent, activation mechanism, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ interaction of MASP-2 with mannan-binding lectin is Ca2+-dependent, the Ca2+-binding site is located in the CUB1 module, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the lectin pathway of complement plays a key role in the immune system by recognising pathogens through patterns of sugar moities displayed on their cell sufaces and neutralizing them in an antibody-independent reaction cascade, MASP-2 binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, interactions analysis, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the lectin pathway of complement plays a key role in the immune system by recognising pathogens through patterns of sugar moities displayed on their cell sufaces and neutralizing them in an antibody-independent reaction cascade, MASP-2 binds to the mannan-binding lectin, MBL, the complex activates the lectin pathway of the complement system, interactions analysis, overview Homo sapiens ?
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?
additional information the enzyme performs proteolytic autoactivation, mannan-binding lectin, MBL, structure and Ca2+-dependent interaction with the enzyme, overview, MAp19 is a product of alternative splicing of the MASP-2 gene and is catalytically inactive, overview Homo sapiens ?
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?

Subunits

Subunits Comment Organism
More domain organizations of MASP-2 and mannan-binding lectin, MBL, overview, the N-terminal third of MASP-2, i.e. MAp19 or sMAp, comprises the CUB1 and EGF modules of MASP-2 plus an extra C-terminal EQSL tetrapeptide, which is encoded by a separate exon, overview, enzyme structure and domain organization: CUB1 module, EGF module, CUB2 module, CCP1, CCP2, and serine protease domains, the very flexible C-terminal catalytic SP region, active site structure, overview Homo sapiens

Synonyms

Synonyms Comment Organism
MASP-2
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Homo sapiens