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Literature summary for 3.4.21.104 extracted from
- Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway (2007), Adv. Exp. Med. Biol., 598, 93-104.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| mannan-binding lectin | a C-type serum lectin acting as a pattern recognition molecule, associated to MASPs, binding triggers activation of MASPs, overview | Mus musculus | |
| mannan-binding lectin | a C-type serum lectin acting as a pattern recognition molecule, associated to MASPs, binding triggers activation of MASPs, overview | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| MASP-2 genetic structure, localization of the gene on chromosome 1p36.3-p36.2, overview, the N-terminal third of MASP-2, i.e. MAp19 or sMAp, comprises the CUB1 and EGF modules of MASP-2 plus an extra C-terminal EQSL tetrapeptide, which is encoded by a separate exon, MAp19 is a product of alternative splicing of the MASP-2 gene, predominantly expressed in liver, and is catalytically inactive | Homo sapiens |
| MASP-2 genetic structure, overview | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of MASP-2-deficient mice, MASP-2-deficient mice show reduced activity for C3 deposition on the surface of mannan and zymosan, lectin complement pathway and phenotype, overview | Mus musculus |
| additional information | MASP-2 deficiency phenotype | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| C2 complement component + H2O | Mus musculus | - |
? | - |
? |  |
| C4 complement component + H2O | Mus musculus | - |
? | - |
? | |
| complement component C2 + H2O | Homo sapiens | - |
? | - |
? | |
| complement component C4 + H2O | Homo sapiens | - |
? | - |
? | |
| additional information | Mus musculus | binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview | ? | - |
? | |
| additional information | Homo sapiens | binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | O00187 | - |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the enzyme performs autoactivation | Mus musculus |
| proteolytic modification | the enzyme performs autoactivation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | expression of the enzyme, both enzyme splicing variants MASP-2 and MAp19 | Homo sapiens | - |
| serum | circulating zymogen as single chain polypeptide | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| C2 complement component + H2O | - |
Mus musculus | ? | - |
? | |
| C4 complement component + H2O | - |
Mus musculus | ? | - |
? | |
| complement component C2 + H2O | - |
Homo sapiens | ? | - |
? | |
| complement component C2 + H2O | formation of C3 convertase C4b2a | Mus musculus | ? | - |
? | |
| complement component C2 + H2O | formation of C3 convertase C4b2a | Homo sapiens | ? | - |
? | |
| complement component C4 + H2O | - |
Homo sapiens | ? | - |
? | |
| complement component C4 + H2O | exclusively cleaves complement C4 | Homo sapiens | ? | - |
? | |
| complement component C4 + H2O | formation of C3 convertase C4b2a | Mus musculus | ? | - |
? | |
| complement component C4 + H2O | formation of C3 convertase C4b2a | Homo sapiens | ? | - |
? | |
| additional information | binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview | Mus musculus | ? | - |
? | |
| additional information | binding of MBL or ficolins to the cell surface carbohydrates of microbes initiates MASP activation, autoactivation of MASP-2 is the first step in the complement cascade, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | enzyme structure and domain organization: CUB1 module, EGF module, CUB2 module, CCP1, CCP2, and serine protease domains, overview | Mus musculus |
| More | enzyme structure and domain organization: CUB1 module, EGF module, CUB2 module, CCP1, CCP2, and serine protease domains, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MASP-2 | - |
Mus musculus |
| MASP-2 | - |
Homo sapiens |
| MASP-2 | exclusively cleaves complement 4 | Homo sapiens |
| MBL-associated serine protease | - |
Mus musculus |
| MBL-associated serine protease | - |
Homo sapiens |
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