Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
D105G | inactive, MASP-2 deficiency, the index case suffers from recurrent severe infections and autoimmune reactions | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
complement C1 inhibitor | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | MASP-2 is associated with mannan-binding lectin II | Homo sapiens | - |
- |
additional information | MASP-2 is associated with mannan-binding lectin II | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | enables dimerization | Homo sapiens | |
Ca2+ | enables dimerization | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
74000 | - |
2 * 74000, SDS-PAGE | Homo sapiens |
74000 | - |
2 * 74000, SDS-PAGE, homodimers are stable in the presence of Ca2+ | Rattus norvegicus |
74150 | - |
monomer, calculated from amino acid sequence | Homo sapiens |
74150 | - |
monomer, calculated from amino acid sequence | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00187 | - |
- |
Rattus norvegicus | Q9JJS8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
blood plasma | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C2 + H2O | - |
Homo sapiens | ? | the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 | ? | |
complement component C2 + H2O | - |
Rattus norvegicus | ? | the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 | ? | |
complement component C4 + H2O | - |
Homo sapiens | ? | the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 | ? | |
complement component C4 + H2O | - |
Rattus norvegicus | ? | the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 | ? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 74000, SDS-PAGE | Homo sapiens |
dimer | 2 * 74000, SDS-PAGE, homodimers are stable in the presence of Ca2+ | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
mannan-binding lectin-associated serine protease-2 | - |
Homo sapiens |
mannan-binding lectin-associated serine protease-2 | - |
Rattus norvegicus |
MASP-2 | - |
Homo sapiens |
MASP-2 | - |
Rattus norvegicus |