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Literature summary for 3.4.21.104 extracted from

  • Sorensen, R.; Thiel, S.; Jensenius, J.C.
    Mannan-binding-lectin-associated serine proteases, characteristics and disease associations (2005), Semin. Immunopathol., 27, 299-319.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
D105G inactive, MASP-2 deficiency, the index case suffers from recurrent severe infections and autoimmune reactions Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
complement C1 inhibitor
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information MASP-2 is associated with mannan-binding lectin II Homo sapiens
-
-
additional information MASP-2 is associated with mannan-binding lectin II Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ enables dimerization Homo sapiens
Ca2+ enables dimerization Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74000
-
2 * 74000, SDS-PAGE Homo sapiens
74000
-
2 * 74000, SDS-PAGE, homodimers are stable in the presence of Ca2+ Rattus norvegicus
74150
-
monomer, calculated from amino acid sequence Homo sapiens
74150
-
monomer, calculated from amino acid sequence Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens O00187
-
-
Rattus norvegicus Q9JJS8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
blood plasma
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
Homo sapiens ? the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 ?
complement component C2 + H2O
-
Rattus norvegicus ? the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 ?
complement component C4 + H2O
-
Homo sapiens ? the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 ?
complement component C4 + H2O
-
Rattus norvegicus ? the complement C3 convertase C4bC2b is generated by cleavage of complement C4 and complement C2 ?

Subunits

Subunits Comment Organism
dimer 2 * 74000, SDS-PAGE Homo sapiens
dimer 2 * 74000, SDS-PAGE, homodimers are stable in the presence of Ca2+ Rattus norvegicus

Synonyms

Synonyms Comment Organism
mannan-binding lectin-associated serine protease-2
-
Homo sapiens
mannan-binding lectin-associated serine protease-2
-
Rattus norvegicus
MASP-2
-
Homo sapiens
MASP-2
-
Rattus norvegicus