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Literature summary for 3.4.21.104 extracted from

  • Feinberg, H.; Uitdehaag, J.C.M.; Davies, J.M.; Wallis, R.; Drickamer, K.; Weis, W.I.
    Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2 (2003), EMBO J., 22, 2348-2359.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.104

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method in the presence of Ca2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Protein + H2O Rattus norvegicus enzyme circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a ASP homodimer bound to two mannose-binding protein trimeric subunits, complex is formed more readily in the presence of Ca2+ ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9JJS8
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification zymogen is cleaved into the catalytically active protease Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) mechanism Rattus norvegicus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Protein + H2O
-
 Rattus norvegicus ?
-
 ?
Protein + H2O enzyme circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a ASP homodimer bound to two mannose-binding protein trimeric subunits, complex is formed more readily in the presence of Ca2+ Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer crystallographic experiments Rattus norvegicus

Synonyms

Synonyms Comment Organism
MASP-2
-
 Rattus norvegicus