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Literature summary for 3.4.21.10 extracted from

  • Gaboriau, D.; Howes, E.A.; Clark, J.; Jones, R.
    Binding of sperm proacrosin/beta-acrosin to zona pellucida glycoproteins is sulfate and stereodependent. Synthesis of a novel fertilization inhibitor (2007), Dev. Biol., 306, 646-657.
    View publication on PubMed
Search for more literature for 3.4.21.10

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition with quercetin-3beta-D-glucoside or quercetin-3beta-D-glucoside sulfate Sus scrofa
NF064
-
 Sus scrofa
NSC651015
-
 Sus scrofa
NSC651016
-
 Sus scrofa
suramin
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa proacrosin involved in stereospecific sulfate binding that mediates the retention of post-acrosome reaction spermatozoa on the zona pellucida surface ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
spermatozoon
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information proacrosin involved in stereospecific sulfate binding that mediates the retention of post-acrosome reaction spermatozoa on the zona pellucida surface Sus scrofa ?
-
 ?
Nalpha-benzoyl-L-arginine 4-nitroanilide hydrochloride + H2O
-
 Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-acrosin residues 1-322, activated form of proacrosin (residues 1-399) Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.012
-
 23°C Sus scrofa NF064
0.1
-
 23°C Sus scrofa suramin
0.7
-
 23°C Sus scrofa NSC651015
0.7
-
 23°C Sus scrofa NSC651016