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Literature summary for 3.4.21.1 extracted from

  • Gesner-Apter, S.; Carmeli, S.
    Protease inhibitors from a water bloom of the cyanobacterium Microcystis aeruginosa (2009), J. Nat. Prod., 72, 1429-1436.
    View publication on PubMed
Search for more literature for 3.4.21.1

Inhibitors

Inhibitors Comment Organism Structure
micropeptin 478-A potent inhibitor synthetic construct
micropeptin 478-B moderate inhibitor synthetic construct
micropeptin HU1021 weak inhibitor synthetic construct
micropeptin HU1041 weak inhibitor synthetic construct
micropeptin HU1069 weak inhibitor synthetic construct
micropeptin HU895A moderate inhibitor synthetic construct
micropeptin HU895B potent inhibitor synthetic construct
micropeptin HU909 potent inhibitor synthetic construct
micropeptin HU975 moderate inhibitor synthetic construct
micropeptin HU989 moderate inhibitor synthetic construct
additional information lowest inhibition concentrations of chymotrypsin for glyceric acid at position 7, while 3-sulfoglyceric acid derivatives are less potent and disulfoglyceric acid derivatives exert much higher IC50's synthetic construct

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for catalysis synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Gly-Gly-p-nitroanilide + H2O
-
 synthetic construct succinyl-Gly-Gly + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
chymotrypsin
-
 synthetic construct

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0028
-
 micropeptin HU909 at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.0052
-
 micropeptin 478-A at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.0054
-
 micropeptin HU895B at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.0182
-
 micropeptin HU989 at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.0196
-
 micropeptin HU895A at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.024
-
 micropeptin HU975 at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.072
-
 micropeptin 478-B at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.1
-
 micropeptin HU1069 at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.1
-
 micropeptin HU1021 at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct
0.1
-
 micropeptin HU1041 at 37°C, in 50 mM Tris-HCl buffer, 100 mM NaCl, 1 mM CaCl2 and 1 mM HCl synthetic construct