Literature summary for 3.4.21.1 extracted from

Bruni, N.; Di Maro, A.; Costantini, S.; Chambery, A.; Facchiano, A.M.; Ficca, A.G.; Parente, A.; Poerio, E.
Redesigning the reactive site loop of the wheat subtilisin/chymotrypsin inhibitor (WSCI) by site-directed mutagenesis. A protein-protein interaction study by affinity chromatography and molecular modeling (2009), Biochimie, 91, 1112-1122.

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Inhibitors

Inhibitors	Comment	Organism	Structure
wheat subtilisin/chymotrypsin inhibitor	as the wild-type inhibitor, the recombinant inhibitor, while acting as a strong subtilisin inhibitor, is much less efficient against alpha-chymotrypsin. Mutant E49S of the wheat subtilisin/chymotrypsin inhibitor shows a limited anti-chymotrypsin activity. Mutants E49P, Y50G and M48P/E49G are inactive against alpha-chymotrypsin	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mutant Y50G of the wheat subtilisin/chymotrypsin inhibitor acts as a common substrate for chymotrypsin	Bos taurus	?	-	?

Synonyms

Synonyms	Comment	Organism
alpha-chymotrypsin	-	Bos taurus

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Release 2023.1 (January 2023)