Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-Benzyl succinate | - |
Rattus norvegicus | |
Cd2+ | - |
Rattus norvegicus | |
Cu2+ | markedly | Rattus norvegicus | |
Fe2+ | not | Rattus norvegicus | |
Hg2+ | - |
Rattus norvegicus | |
additional information | 2-mercaptoethanol; DTT; N3-; not: EDTA | Rattus norvegicus | |
phenylmethanesulfonyl fluoride | weak | Rattus norvegicus | |
Zn2+ | moderate | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
Acetyl-Met-Leu | - |
Rattus norvegicus | |
0.04 | - |
N-Formyl-Met-Leu | - |
Rattus norvegicus | |
0.06 | - |
N-Formyl-Met-Val | - |
Rattus norvegicus | |
0.16 | - |
Acetyl-Met-Leu-Phe | - |
Rattus norvegicus | |
0.18 | - |
N-Formyl-Met-Leu-Phe | - |
Rattus norvegicus | |
0.22 | - |
N-Formyl-Met-Leu-Tyr | - |
Rattus norvegicus | |
0.23 | - |
Formylnorleucine-Leu-Phe | - |
Rattus norvegicus | |
0.63 | - |
N-Formyl-Met-Phe | - |
Rattus norvegicus | |
0.71 | - |
N-Formyl-Met-Trp | - |
Rattus norvegicus | |
1.7 | - |
N-Formyl-Met 2-naphthylamide | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cl- | activates | Rattus norvegicus | |
Cl- | maximal activity at 1 M | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-Formylmethionyl oligopeptides + H2O | Rattus norvegicus | the presence of this enzyme in intestinal mucosa can prevent absorption of intact bioactive potent inflammatory N-formylmethionyl oligopeptides produced by commensal bacteria in the gut lumen | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
intestine | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gut | lowest level in oesophagus and stomach and a shallow diminishing gradient from proximal small intestine to distal colon and rectum | Rattus norvegicus | - |
intestine | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
12.86 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Acetyl-Met-Leu + H2O | - |
Rattus norvegicus | ? | - |
? | |
Acetyl-Met-Leu-Phe + H2O | - |
Rattus norvegicus | ? | - |
? | |
Formylnorleucine-Leu-Phe + H2O | - |
Rattus norvegicus | ? | - |
? | |
N-Formyl-Met 2-naphthylamide + H2O | - |
Rattus norvegicus | N-Formyl-Met + 2-naphthylamine | - |
? | |
N-Formyl-Met-Leu + H2O | - |
Rattus norvegicus | N-Formyl-Met + Leu | - |
? | |
N-Formyl-Met-Leu-Phe + H2O | - |
Rattus norvegicus | N-Formyl-Met + Leu-Phe | - |
? | |
N-Formyl-Met-Leu-Tyr + H2O | - |
Rattus norvegicus | N-Formyl-Met + Leu-Tyr | - |
? | |
N-Formyl-Met-Phe + H2O | - |
Rattus norvegicus | N-Formyl-Met + Phe | - |
? | |
N-Formyl-Met-Trp + H2O | - |
Rattus norvegicus | N-Formyl-Met + Trp | - |
? | |
N-Formyl-Met-Val + H2O | - |
Rattus norvegicus | N-Formyl-Met + Val | - |
? | |
N-Formylmethionyl oligopeptides + H2O | the presence of this enzyme in intestinal mucosa can prevent absorption of intact bioactive potent inflammatory N-formylmethionyl oligopeptides produced by commensal bacteria in the gut lumen | Rattus norvegicus | ? | - |
? | |
Natural formylmethionine oligopeptide from E. coli culture supernatants + H2O | loss of bioactivity and immuno-reactivity | Rattus norvegicus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5.17 | - |
N-Formyl-Met-Leu | - |
Rattus norvegicus | |
5.45 | - |
Acetyl-Met-Leu | - |
Rattus norvegicus | |
5.94 | - |
N-Formyl-Met-Val | - |
Rattus norvegicus | |
12.3 | - |
N-Formyl-Met-Leu-Phe | - |
Rattus norvegicus | |
15.5 | - |
N-Formyl-Met-Leu-Tyr | - |
Rattus norvegicus | |
27.1 | - |
Acetyl-Met-Leu-Phe | - |
Rattus norvegicus | |
31.3 | - |
N-Formyl-Met-Trp | - |
Rattus norvegicus | |
70.2 | - |
N-Formyl-Met-Phe | - |
Rattus norvegicus | |
76.4 | - |
N-Formyl-Met 2-naphthylamide | - |
Rattus norvegicus |