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Literature summary for 3.4.19.2 extracted from

  • Simmons, W.H.; Walter, R.
    Carboxamidopeptidase: purification and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin (1980), Biochemistry, 19, 39-48.
    View publication on PubMed
Search for more literature for 3.4.19.2

Inhibitors

Inhibitors Comment Organism Structure
4-methylumbelliferyl p-guanidinobenzoate
-
 toad
antipain
-
 toad
chymostatin
-
 toad
concanavalin A
-
 toad
diisopropyl phosphofluoridate
-
 toad
Elastatinal
-
 toad
leupeptin
-
 toad
Lima bean trypsin inhibitor
-
 toad
ovoinhibitor
-
 toad
ovomucoid
-
 toad
p-Nitrophenyl p-guanidinobenzoate
-
 toad
PCMB reversed by Cys toad
tosyllysine chloromethyl ketone
-
 toad
tosylphenylalanine chloromethyl ketone
-
 toad
Trasylol
-
 toad

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 2 * 48000, each subunit consists of a heavy chain, 28000 da, and a light chain, 19000 Da joined by a disulfide bond, SDS-PAGE toad
100000
-
 gel filtration toad

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information toad enzyme inactivates neurophyseal hormones ?
-
 ?

Organism

Organism UniProt Comment Textmining
toad
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 toad

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
 toad
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-L-Trp ethyl ester + H2O
-
 toad ?
-
 ?
benzoyl-L-Arg ethyl ester + H2O
-
 toad ?
-
 ?
additional information enzyme inactivates neurophyseal hormones toad ?
-
 ?
oxytocin + H2O hydrolysis of the Leu8-Gly9-NH2 bond toad glycinamide + ?
-
 ?
[Arg8]-vasopressin + H2O hydrolysis of the Arg8-Gly9-NH2 bond toad ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 48000, each subunit consists of a heavy chain, 28000 da, and a light chain, 19000 Da joined by a disulfide bond, SDS-PAGE toad

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 oxytocin toad
7.5 8.5 hydrolysis of 8-arginine-vasopressin or benzoyl-L-Arg ethyl ester toad