Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acivicin | - |
Mus musculus | |
additional information | GSH is not a competitive inhibitor of gamma-glutamyl leukotrienase, since even an 80fold molar excess of GSH in the reaction mixture does not alter the rate of cleavage of leukotriene C4 | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
leukotriene C4 | in 0.1 M Tris-HCl buffer, pH 8.0, at 37°C | Mus musculus | |
0.03 | - |
S-decyl-GSH | in 0.1 M Tris-HCl buffer, pH 8.0, at 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
papain-cleaved enzyme, gel filtration | Mus musculus |
65000 | - |
papain-cleaved enzyme, sedimentation velocity centrifugation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
pancreas | - |
Mus musculus | - |
small intestine | - |
Mus musculus | - |
spleen | highest activity in spleen | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene C4 + H2O | inclusion of Gly-Gly in the incubation mixture does not significantly enhance the conversion of leukotriene C4 to leukotriene D4 | Mus musculus | leukotriene D4 + L-glutamate | - |
? | |
additional information | the enzyme does not cleave GSH or GSSG, gamma-glutamyl-4-nitroanilide, and gamma-glutamyl-4-methoxy-2-naphthylamide | Mus musculus | ? | - |
? | |
S-decyl-GSH + H2O | the substrate has the strongest binding among all of the S-alkyl-GSH analyzed and has binding activity similar to leukotriene C4 | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutamyl leukotrienase | - |
Mus musculus |
GGL | - |
Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | 60 | at 60°C for 5 min completely inactivates cleavage of LTC4, while at 37°C the enzyme is active for as long as 5 h | Mus musculus |