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Literature summary for 3.4.19.13 extracted from
- Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase (1993), Biochemistry, 32, 6302-6306.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in NIH/3T3 cell | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | construction of stably transfected NIH/3T3 mouse fibroblasts that express the enzyme in its proper orientation on the outer surface of the cell. NIH/3T3 fibroblasts require cysteine for growth and are unable to use extracellular glutathione as a source of cysteine. NIH/3T3 fibroblasts expressing the enzyme are able to grow in cysteine-free medium supplemented with glutathione. Cysteine derived from the cleavage of extracellular glutathione can be used to maintain intracellular levels of glutathione, and cells are able to replenish intracellular glutathione when incubated in cysteine-free medium containing glutathione | Homo sapiens |
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