Literature summary for 3.4.19.13 extracted from

Accaoui, M.; Enoiu, M.; Mergny, M.; Masson, C.; Dominici, S.; Wellman, M.; Visvikis, A.
Gamma-glutamyltranspeptidase-dependent glutathione catabolism results in activation of NF-kB (2000), Biochem. Biophys. Res. Commun., 276, 1062-1067.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in V79 fibroblast cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	extracellular cleavage of glutathione by the enzyme leads to reactive oxygen species production, depending on the generation and enhanced reactivity of cysteinylglycine. This production of reactive oxygen species induces the NF-kappaB-binding and transactivation activities. The induction mimicks the one observed by H2O2 and is inhibited by catalase	Homo sapiens

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Release 2023.1 (January 2023)