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Literature summary for 3.4.19.13 extracted from

  • Wickham, S.; West, M.; Cook, P.; Hanigan, M.
    Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes (2011), Anal. Biochem., 414, 208-214.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
serine borate competitive, 8fold less effective as an inhibitor of isoform GGT5 than of GGT1; competitive, 8fold less effective as an inhibitor of isoform GGT5 than of GGT1 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0088
-
oxidized glutathione pH 7.4, 37°C Homo sapiens
0.0102
-
leukotriene C4 pH 7.4, 37°C Homo sapiens
0.0105
-
reduced glutathione pH 7.4, 37°C Homo sapiens
0.0106
-
reduced glutathione pH 7.4, 37°C Homo sapiens
0.0108
-
leukotriene C4 pH 7.4, 37°C Homo sapiens
0.0131
-
S-(4-nitro-benzyl)glutathione pH 7.4, 37°C Homo sapiens
0.0148
-
S-(4-nitro-benzyl)glutathione pH 7.4, 37°C Homo sapiens
0.0182
-
S-Methylglutathione pH 7.4, 37°C Homo sapiens
0.0334
-
gamma-glutamyl L-leucine pH 7.4, 37°C Homo sapiens
0.0346
-
glutathione sulfonic acid pH 7.4, 37°C Homo sapiens
0.0426
-
oxidized glutathione pH 7.4, 37°C Homo sapiens
0.0751
-
glutathione sulfonic acid pH 7.4, 37°C Homo sapiens
0.099
-
S-Methylglutathione pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P19440
-
-
Homo sapiens P36269
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-glutamyl L-leucine + H2O
-
Homo sapiens L-leucine + L-glutamate
-
?
glutathione sulfonic acid + H2O
-
Homo sapiens ? + L-glutamate
-
?
leukotriene C4 + H2O
-
Homo sapiens ?
-
?
additional information no substrate: gamma-glutamyl L-leucine Homo sapiens ?
-
?
additional information protein additionally has EC 2.3.2.2, gamma-glutamyltransferase activity Homo sapiens ?
-
?
oxidized glutathione + H2O
-
Homo sapiens ? + L-glutamate
-
?
reduced glutathione + H2O
-
Homo sapiens L-cysteinylglycine + L-glutamate
-
?
S-(4-nitro-benzyl)glutathione + H2O
-
Homo sapiens S-(4-nitro-benzyl)-L-cysteinylglycine + L-glutamate
-
?
S-methylglutathione + H2O
-
Homo sapiens S-methyl-L-cysteinylglycine + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
gamma-glutamyl transpeptidase
-
Homo sapiens
GGT1
-
Homo sapiens
GGT5
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2
-
serine borate pH 7.4, 37°C Homo sapiens