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Literature summary for 3.4.19.12 extracted from

  • Hartnett, S.; Zhang, F.; Abitz, A.; Li, Y.
    Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells (2014), Neurosci. Lett., 564, 115-119.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol only localization Mus musculus 5829
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9R0P9
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Source Tissue

Source Tissue Comment Organism Textmining
SN-56 cell cholinergic neuronal cell line Mus musculus
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General Information

General Information Comment Organism
physiological function isoform UCHL1 physically interacts with high affinity choline transporter CHT, which is a key protein regulating Ach re-synthesis. Reduction of UCHL1 by siRNA gene knockdown significantly increases polyubiquitinated CHT and decreased native CHT protein level, but does not affect CHT mRNA expression. Gene knockdown of UCHL1 significantly reduces cytosolic CHT but has no significant effect on membrane CHT level Mus musculus