Protein Variants | Comment | Organism |
---|---|---|
C90S | mutant shows same interaction pattern as wild-type. Mutant shows no hydrolase activity | Homo sapiens |
D176A | mutant shows an increased interaction with CDK4 compared to wild-type | Homo sapiens |
DELTA148-190 | deletion mutant containing amino acids 148-190 interacts with CDK4 | Homo sapiens |
DELTA148-223 | deletion mutant containing amino acids 148-223 interacts with CDK4 | Homo sapiens |
DELTA160-190 | deletion mutant containing amino acids 160-190 interacts with CDK4 | Homo sapiens |
DELTA160-223 | deletion mutant containing amino acids 160-223 interacts with CDK4 | Homo sapiens |
DELTA188-223 | deletion mutant containing amino acids 188-223 does not interact with CDK4 | Homo sapiens |
E174A | mutant shows an increased interaction with CDK4 compared to wild-type | Homo sapiens |
H165A | mutant shows an increased interaction with CDK4 compared to wild-type | Homo sapiens |
I93M | mutant shows a stronger interaction with CDK1, CDK4 and CDK5 compared to wild-type. Hydrolase and ligase activity are reduced in mutant compared to wild-type | Homo sapiens |
R63A | mutant shows an increased interaction with CDK4 compared to wild-type | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09936 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
UCH-L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | gain- and loss of-function studies reveals that UCH-L1 enhances proliferation of multiple cell types | Homo sapiens |
malfunction | RNA interference of UCH-L1 reduces the growth of human xenograft tumors in mice | Homo sapiens |
physiological function | UCH-L1 physically interacts with CDK1, CDK4, and CDK5, enhancing their kinase activity | Homo sapiens |