Literature summary for 3.4.19.12 extracted from

Wulfaenger, J.; Biehl, K.; Tetzner, A.; Wild, P.; Ikenberg, K.; Meyer, S.; Seliger, B.
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma (2013), Int. J. Cancer, 133, 2522-2532.

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Application

Application	Comment	Organism
medicine	melanoma cells show a a widespread loss or reduced expression of ubiquitin C-terminal hydrolase UCHL1, which is directly correlated with promoter DNA hypermethylation. The subset of melanoma cells, which still express UCHL1, shows altered growth properties and tolerances against reactive oxygen species as compared to UCHL1-negative cells. UCHL1 may function as a new diagnostic biomarker or therapeutic target for the treatment of UCHL1-positive melanomas	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell line	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	melanoma cells show a a widespread loss or reduced expression of ubiquitin C-terminal hydrolase UCHL1, which is directly correlated with promoter DNA hypermethylation. The subset of melanoma cells, which still express UCHL1, shows altered growth properties and tolerances against reactive oxygen species as compared to UCHL1-negative cells	Homo sapiens

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Release 2023.1 (January 2023)