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Literature summary for 3.4.19.12 extracted from

  • Song, H.M.; Lee, J.E.; Kim, J.H.
    Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines (2014), Biochem. Biophys. Res. Commun., 452, 722-727.
    View publication on PubMed
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Application

Application Comment Organism
medicine ubiquitin C-terminal hydrolase UCH-L3 is upregulated in normal or non-metastatic prostate cancer cells and is downregulated in metastatic prostate cancer cell lines. Knockdown of UCH-L3 in normal prostate cell line RWPE1 promotes epithelial-to-mesenchymal transition, an important process for cancer cell invasion and metastasis. The induction of epithelial-to-mesenchymal transition by UCH-L3 knockdown results in an increase of cell migration and invasion. Overexpression of UCH-L3 in highly metastatic prostate cancer cell line PC3 reverses epithelial-to-mesenchymal transition but an active site mutant of UCH-L3 does not Homo sapiens

Protein Variants

Protein Variants Comment Organism
C95S active-site mutant. In highly metastatic prostate PC-3 cells, presence of UCH-L3 inhibits the cell migration and invasion but mutant C95S has no effects Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15374
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
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 Homo sapiens
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RWPE-1 cell human prostate cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
Uchl3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ubiquitin C-terminal hydrolase UCH-L3 is upregulated in normal or non-metastatic prostate cancer cells and is downregulated in metastatic prostate cancer cell lines additional information

General Information

General Information Comment Organism
physiological function ubiquitin C-terminal hydrolase UCH-L3 is upregulated in normal or non-metastatic prostate cancer cells and is downregulated in metastatic prostate cancer cell lines. Knockdown of UCH-L3 in normal prostate cell line RWPE1 promotes epithelial-to-mesenchymal transition, an important process for cancer cell invasion and metastasis. The induction of epithelial-to-mesenchymal transition by UCH-L3 knockdown results in an increase of cell migration and invasion. Overexpression of UCH-L3 in highly metastatic prostate cancer cell line PC3 reverses epithelial-to-mesenchymal transition but an active site mutant of UCH-L3 does not Homo sapiens