Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DTT | required, hydrolase activity of UCH-L1 in vitro is decreased when reducing dithiothreitol is omitted from the reaction buffer | Mus musculus | |
additional information | UCH-L1 is easily affected by redox status | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deficiency of UCH-L1 of gad mice, i.e. UCH-L1-deficient mutant gracile axonal dystrophy mice, leads to vulnerability to lipid peroxidation both in vivo and in vitro. When neurons from dorsal root ganglions are cultured in the vitamin E-free medium, cell death is increased in the neurons of gad mice. Oxidative stress, especially lipid peroxidation, augments the neuronal cell death of gad mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | UCH-L1 is easily affected by redox status | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | UCH-L1 itself is a soluble protein and has no transmembrane domain, but UCH-L1 directly and specifically binds to phosphatidic acid thereby interacting with the menbrane | Mus musculus | 5829 | - |
plasma membrane | UCH-L1 itself is a soluble protein and has no transmembrane domain, but UCH-L1 directly and specifically binds to phosphatidic acid thereby interacting with the menbrane. Monoubiquitin can possibly regulate the interaction between UCH-L1 and phosphatidic acid since bound UCH-L1 is increased in the presence of monoubiquitin | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | cysteine residues of UCH-L1 are readily carbonylated by 4-hydroxy-2-nonenal or other unsaturated aldehydes, and the carbonylated UCH-L1 exhibits altered properties in hydrolase activity and protein-protein interactions | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | UCH-L1 is localized on the inside of the plasma membrane of dorsal root ganglion neurons | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxy-terminal hydrolase-L1 | - |
Mus musculus |
ubiquitin carboxyterminal hydrolase-L1 | - |
Mus musculus |
UCH-L1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency of UCH-L1 leads to vulnerability to lipid peroxidation both in vivo and in vitro | Mus musculus |