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Literature summary for 3.4.19.12 extracted from

  • Pfeffer, M.; Plenzig, S.; Gispert, S.; Wada, K.; Korf, H.W.; Von Gall, C.
    Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene (2012), Neurobiol. Aging, 33, 393-403.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information melanopsin-Ir is significantly reduced in the retina of gracile axonal dystrophy, i.e. gad, mice with a spontaneous deletion in the Uch-l1 gene, resulting in impairment of circadian light perception in gad mice, overview. In constant darkness, gad mice show circadian rhythms in locomotor activity, indicating the integrity of the endogenous circadian rhythm generator. In addition, gad mice show increased locomotor activity in the light period when kept in a standard photoperiod and entrainment to phase shifts is significantly slower than in wild-type mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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gene uch-L1
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Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus lateral Mus musculus
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neuronal cell
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Mus musculus
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retina
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Mus musculus
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Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase L1
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Mus musculus
UCH-L1
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Mus musculus