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Literature summary for 3.4.19.12 extracted from
- Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis (2009), Endocrinology, 150, 5230-5239.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Uchl3-deficient mice show reduced content of white adipose tissue and reduced adipogenesis due to attenuated insulin responses, ectopic expression of wild-type UCH-L3 restores the phosphorylation of insulin/IGF-I receptor and adipocyte differentiation in UCH-L3-/- mouse embyronic fibroblasts, overview. Hydrolase-deficient UCH-L3 does not enhance insulin signalling and expression of gluta4, fabp4, and adiponectin, resulting in impaired formation of large lipid droplets | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| epididymis | - |
Mus musculus | - |
| fibroblast | embryonic | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ubiquitin carboxyl-terminal hydrolase l3 | - |
Mus musculus |
| UCH-L3 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | ectopic expression of UCH-L3 promotes the phosphorylation of insulin/IGF-I receptor and adipocyte differentiation in fibroblasts, overview | Mus musculus |
| physiological function | UCH-L3 promotes insulin signaling and adipogenesis | Mus musculus |
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