Cloned (Comment) | Organism |
---|---|
expression of GST-tagged wild-type and mutant enzymes in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
I93M | naturally occuring mutation of Uch-L1 involved in the Parkinson's disease | Homo sapiens |
S18Y | naturally occuring mutation of Uch-L1 involved in the Huntington's disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | interaction of the ubiquitin carboxyl terminal esterase L1 with alpha2-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation. Uch-L1 binds specifically to the third intracellular loop of alpha2A adrenergic receptor, but also to the respective loops of adrenergic receptors alpha2B, alpha2C, and beta2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | interaction of the ubiquitin carboxyl terminal esterase L1 with alpha2-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation. Uch-L1 binds specifically to the third intracellular loop of alpha2A adrenergic receptor, but also to the respective loops of adrenergic receptors alpha2B, alpha2C, and beta2, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl terminal esterase L1 | - |
Homo sapiens |
ubiquitin carboxyl-terminal hydrolase-L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Uch-L1 is associated with Parkinson's disease, as alpha2-adrenergic receptor interacting protein. alpha2-Adrenergic receptor agonist-mediated activation of p44/42MAP kinase is drastically decreased in the presence of Uch-L1. Stimulation of recombinantly UCH-L1 expressing HEK-293 cells prior lysis with norepinephrine, yohimbine, phentolamine or moxonidine does also not significantly affect the interaction, as well as co-transfection of arrestin-3 or spinophilin-(Phe151-Lys446) | Homo sapiens |
physiological function | Uch-L1 is involved in controling alpha2-adrenergic receptor receptor function and trafficking, it binds preferentially to the alpha2A-adrenergic receptor subtype and only with less affinity to alpha2B-adrenergic receptor and alpha2C-adrenergic receptor, specific interaction in vivo, mechanism, overview | Homo sapiens |