Protein Variants | Comment | Organism |
---|---|---|
additional information | mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis. Cultured osteoclast precursors derived from CYLD-deficient mice are hyperresponsive to RANKL-induced differentiation and produce more and larger osteoclasts than do controls upon stimulation | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | CYLD negatively regulates RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events. CYLD interacts physically with the signaling adaptor p62 and thereby is recruited to TRAF6. CYLD is a crucial negative regulator of osteoclastogenesis and may be involved in the p62/TRAF6 signaling axis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q80TQ2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | expression level of CYLD is extremely low | Mus musculus | - |
preosteoclast | CYLD is drastically upregulated during RANKL-induced differentiation of preosteoclasts | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CYLD negatively regulates RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events. CYLD interacts physically with the signaling adaptor p62 and thereby is recruited to TRAF6. CYLD is a crucial negative regulator of osteoclastogenesis and may be involved in the p62/TRAF6 signaling axis | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYLD | - |
Mus musculus |