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Literature summary for 3.4.19.12 extracted from

  • Chang, C.; Chang, A.Y.W.; Chan, S.H.H.
    De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication (2004), Shock, 22, 575-581.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Sprague-Dawley rats
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Rattus norvegicus Q00981
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Source Tissue

Source Tissue Comment Organism Textmining
medulla oblongata rostral ventrolateral, expression analysis of isozyme UCH-L1 during mevinphos intoxication, overview Rattus norvegicus
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neuron
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Rattus norvegicus
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rostral ventrolateral medulla de novo synthesis of UCH-L1, leading to an enhanced dissassembly of ubiquitin-protein conjugates in the rostral ventrolateral medulla, is essential to maintenance of the pro-life phase of mevinphos intoxication via prevention of cardiovascular depression, leading to neuroprotection Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase
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Rattus norvegicus
UCH
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Rattus norvegicus
UCH-L1
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Rattus norvegicus