Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the full length UCH-L1 is a de-ubiquinating enzyme in brain, and a major target of oxidative damage in Alzheimer's diesease and Parkinson's disease brains, modified by cysteine and methionine oxidation and carbonyl formation | ? | - |
? | |
additional information | Homo sapiens | oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
3 isozymes of UCH-L1 | - |
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | frontal cortex of healthy, Alzheimer's disease, and Parkinson's disease brains, 3 isozymes of UCH-L1, UCH-L1 is down-regulated in Alzheimer's diesease and Parkinson's disease brains | Homo sapiens | - |
brain | oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases | Homo sapiens | - |
additional information | proteomic analysis | Homo sapiens | - |
neurofibrillary tangle | associated to | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the full length UCH-L1 is a de-ubiquinating enzyme in brain, and a major target of oxidative damage in Alzheimer's diesease and Parkinson's disease brains, modified by cysteine and methionine oxidation and carbonyl formation | Homo sapiens | ? | - |
? | |
additional information | oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |