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Literature summary for 3.4.19.12 extracted from

  • Naviglio, S.; Mattecucci, C.; Matoskova, B.; Nagase, T.; Nomura, N.; Di Fiore, P.P.; Draetta, G.F.
    UBPY: a growth-regulated human ubiquitin isopeptidase (1998), EMBO J., 17, 3241-3250.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.12

Cloned(Commentary)

Cloned (Comment) Organism
UBPY, DNA sequence determination and analysis, expression of gene fragment, residues 9-188, fused to GST in a bacterial expression system Homo sapiens
UBPY, expression of wild-type enzyme and mutant D786A in NIH 3T3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C786A site-directed mutagenesis, no activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide UBPY Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
 x * 130000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme inhibits cell proliferation ?
-
 ?
additional information Homo sapiens enzyme regulation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P40818 UBPY
-

Purification (Commentary)

Purification (Comment) Organism
recombinant truncated GST-fusion protein of UBPY Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
C33A cell human cervical carcinoma cell line Homo sapiens
-
fibroblast accumulated upon growth stimulation of starved human fibroblasts Homo sapiens
-
U2-OS cell human osteosarcoma cell line Homo sapiens
-
WI-38 cell human fibroblast cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
branched polyubiquitin + H2O isopeptide-linked ubiquitin chains Homo sapiens ubiquitin
-
 ?
additional information enzyme inhibits cell proliferation Homo sapiens ?
-
 ?
additional information enzyme regulation Homo sapiens ?
-
 ?
polyubiquitin + H2O linear chains Homo sapiens ubiquitin
-
 ?

Subunits

Subunits Comment Organism
? x * 130000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UBPY
-
 Homo sapiens