Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.19.12 extracted from

  • Lam, Y.A.; DeMartino, G.N.; Pickart, C.M.; Cohen, R.E.
    Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes (1997), J. Biol. Chem., 272, 28438-28446.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ubiquitin
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km with several mutant ubiquitin substrates Bos taurus
0.0033
-
wild-type di-ubiquitin pH 8.0, 37°C Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information PA700 regulatory complex of 26S proteasome Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
di-ubiquitin + H2O active with wild-type and mutant di-ubiquitin, the latter contains a distal mutant ubiquitin L8A/I44A Bos taurus ubiquitin
-
?
polyubiquitin + H2O hydrolysis is restricted to the distal end of the substrate, i.e. ubiquitin farthest from the site of protein attachment in poly-ubiquitin conjugates Bos taurus ubiquitin
-
?
polyubiquitin + H2O active with Lys48-, Lys6-, and Lys11-linked poly-ubiquitins Bos taurus ubiquitin
-
?
polyubiquitin + H2O no activity with poly-ubiquitins that contain a distal mutant ubiquitin L8A/I44A Bos taurus ubiquitin
-
?
wild-type di-ubiquitin + H2O
-
Bos taurus ubiquitin
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information rate with several ubiquitin mutant substrates Bos taurus
0.0728
-
wild-type di-ubiquitin pH 8.0, 37°C Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
ubiquitin pH 8.0, 37°C Bos taurus