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Literature summary for 3.4.19.12 extracted from

  • Wilkinson, K.D.
    Ubiquitin C-terminal hydroase (1998), Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press, , 660-663.
No PubMed abstract available
Search for more literature for 3.4.19.12

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol active-site thiol is very sensitive to oxidation and requires reductants Drosophila melanogaster
2-mercaptoethanol active-site thiol is very sensitive to oxidation and requires reductants Homo sapiens
2-mercaptoethanol active-site thiol is very sensitive to oxidation and requires reductants Rattus norvegicus
2-mercaptoethanol active-site thiol is very sensitive to oxidation and requires reductants Bos taurus
DTT active-site thiol is very sensitive to oxidation and requires reductants Drosophila melanogaster
DTT active-site thiol is very sensitive to oxidation and requires reductants Homo sapiens
DTT active-site thiol is very sensitive to oxidation and requires reductants Rattus norvegicus
DTT active-site thiol is very sensitive to oxidation and requires reductants Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ubiquitin-peptide + H2O Drosophila melanogaster
-
 ?
-
 ?
ubiquitin-peptide + H2O Homo sapiens
-
 ?
-
 ?
ubiquitin-peptide + H2O Rattus norvegicus
-
 ?
-
 ?
ubiquitin-peptide + H2O Bos taurus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 UCH-L1, SwissProt: P23356, PIR: S17561, B40085
-
Drosophila melanogaster
-
 SwissProt: P35122, PIR: S33955
-
Homo sapiens
-
 UCH-L1, SwissProt: P09936, PIR: A25865, UCH-L3, SwissProt: P15374, PIR: A40085
-
Rattus norvegicus
-
 UCH-L1, SwissProt: Q00981
-

Oxidation Stability

Oxidation Stability Organism
active-site thiol is very sensitive to oxidation and requires reductants Drosophila melanogaster
active-site thiol is very sensitive to oxidation and requires reductants Homo sapiens
active-site thiol is very sensitive to oxidation and requires reductants Rattus norvegicus
active-site thiol is very sensitive to oxidation and requires reductants Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain accounts for about 2% of soluble protein in brain Homo sapiens
-
nurse cell
-
 Drosophila melanogaster
-
ovary
-
 Drosophila melanogaster
-
testis
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ubiquitin-peptide + H2O
-
 Drosophila melanogaster ?
-
 ?
ubiquitin-peptide + H2O
-
 Homo sapiens ?
-
 ?
ubiquitin-peptide + H2O
-
 Rattus norvegicus ?
-
 ?
ubiquitin-peptide + H2O
-
 Bos taurus ?
-
 ?
ubiquitinyl-peptide + H2O catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin Drosophila melanogaster ubiquitin + peptide
-
 ?
ubiquitinyl-peptide + H2O catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin Homo sapiens ubiquitin + peptide
-
 ?
ubiquitinyl-peptide + H2O catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin Rattus norvegicus ubiquitin + peptide
-
 ?
ubiquitinyl-peptide + H2O catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin Bos taurus ubiquitin + peptide
-
 ?

Synonyms

Synonyms Comment Organism
More peptidase classification: clan CA, family C12, Merops ID: C12.001 Drosophila melanogaster
More peptidase classification: clan CA, family C12, Merops ID: C12.001 Homo sapiens
More peptidase classification: clan CA, family C12, Merops ID: C12.001 Rattus norvegicus
More peptidase classification: clan CA, family C12, Merops ID: C12.001 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Drosophila melanogaster
7.5
-
-
 Homo sapiens
7.5
-
-
 Rattus norvegicus
7.5
-
-
 Bos taurus