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Literature summary for 3.4.19.1 extracted from
- Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase (2007), J. Toxicol. Environ. Health B Crit. Rev., 10, 623-630.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of acylpeptide hydrolase activity is related to cognitive improvement. Potential biomarker for organophosphate exposure in the screening for neurotoxicity. Possible participation of acylpeptide hydrolase in processes of synaptic plasticity. May play a predominant role in the control of presynaptic biopeptide concentrations that are contained in synaptic vesicles and released to the synaptic space exerting a neuromodular effect at a postsynaptic level | Sus scrofa |
| medicine | reliable biomarker for some organophosphate pesticides that show higher specificity for acylpeptide hydrolase than for cholinesterases | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dichlorvos | shows selectivity for acylpeptide hydrolase inhibition in vivo | Homo sapiens |  |
| dichlorvos | exhibits high affinity for acylpeptide hydrolase, possibly blocks its activity toward N-acylpeptide | Sus scrofa | |
| diisopropyl fluorophosphate | - |
Homo sapiens | |
| diisopropyl fluorophosphate | - |
Sus scrofa | |
| additional information | acylpeptide hydrolase is a direct target for some organophosphate compounds | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acylpeptide + H2O | acylpeptide hydrolase catalyzes the hydrolysis of short peptides of the type Nalpha-acyl to form an acyl amino acid and a peptide with a free N-terminus | Sus scrofa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acylpeptide hydrolase | - |
Homo sapiens |
| acylpeptide hydrolase | - |
Sus scrofa |
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