Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.19.1 extracted from

  • Richards, P.G.; Johnson, M.K.; Ray, D.E.
    Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs (2000), Mol. Pharmacol., 58, 577-583.
    View publication on PubMed
Search for more literature for 3.4.19.1

Inhibitors

Inhibitors Comment Organism Structure
chlorfenvinphos IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa
chlorpyrifos-methyl oxon IC50 at pH 7.4, 37°C: 18.3 nM Sus scrofa
DFP IC50 at pH 7.4, 37°C: 22.5 nM Sus scrofa
diazoxon IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa
dichlorvos IC50 at pH 7.4, 37°C: 118.6 nM Sus scrofa
malaoxon IC50 at pH 7.4, 37°C: 1400000 nM Sus scrofa
Mipafox IC50 at pH 7.4, 37°C: 3013 nM Sus scrofa
paraoxon IC50 at pH 7.4, 37°C: 3805 nM Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Sus scrofa 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa the enzyme may be involved in regulation of neuropeptide turnover ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme may be involved in regulation of neuropeptide turnover Sus scrofa ?
-
 ?
N-acetyl-Ala-p-nitroanilide + H2O
-
 Sus scrofa N-acetyl-Ala + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
acylpeptide hydrolase
-
 Sus scrofa
OP85
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000183
-
 IC50 at pH 7.4, 37°C: 18.3 nM Sus scrofa chlorpyrifos-methyl oxon
0.0000225
-
 IC50 at pH 7.4, 37°C: 22.5 nM Sus scrofa DFP
0.0001186
-
 IC50 at pH 7.4, 37°C: 118.6 nM Sus scrofa dichlorvos
0.001386
-
 IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa diazoxon
0.001386
-
 IC50 at pH 7.4, 37°C: 1386 nM Sus scrofa chlorfenvinphos
0.003013
-
 IC50 at pH 7.4, 37°C: 3013 nM Sus scrofa Mipafox
0.003805
-
 IC50 at pH 7.4, 37°C: 3805 nM Sus scrofa paraoxon
1.4
-
 IC50 at pH 7.4, 37°C: 1400000 nM Sus scrofa malaoxon