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Literature summary for 3.4.18.1 extracted from
- Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation (2017), Neuropharmacology, 114, 88-100 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | cathepsin X inhibitor causes neuroprotection via its inhibition of the activation of microglia. Cathepsin X can be a potential therapeutic target for neuroinflammatory disorders | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMS36 | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9WUU7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BV-2 cell | microglial cell | Mus musculus | - |
| EOC-13.31 cell | microglial cell | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | there is a significant release of cathepsin X from activated BV2 and EOC 13.31 cells following a lipopolysaccharide stimulus that coincides with reduced release of the active form of gamma-enolase | Mus musculus |
| physiological function | up-regulated expression and increased release and activity of microglial cathepsin X leads to microglia activation-mediated neurodegeneration | Mus musculus |
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