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Literature summary for 3.4.18.1 extracted from

  • Sevenich, L.; Schurigt, U.; Sachse, K.; Gajda, M.; Werner, F.; Mueller, S.; Vasiljeva, O.; Schwinde, A.; Klemm, N.; Deussing, J.; Peters, C.; Reinheckel, T.
    Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice (2010), Proc. Natl. Acad. Sci. USA, 107, 2497-2502.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.18.1

Protein Variants

Protein Variants Comment Organism
additional information generation of Ctsz null mice and crossing with Ctsb-deficient mice harboring a transgene for the mammary duct-specific expression of polyoma middle T oncogene, PymT. The double mutant mice show significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading, as well as a 70% reduction in the number of lung metastases and an 80% reduction in the size of these metastases. The double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
cathepsin P
-
 Mus musculus
cathepsin X
-
 Mus musculus
cathepsin Z
-
 Mus musculus
CTSZ
-
 Mus musculus

General Information

General Information Comment Organism
physiological function synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice, overview Mus musculus