Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | cathepsin X is localized on the cell surface of primary osteoblasts | Homo sapiens | 9986 | - |
extracellular | secretion | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CXCL-12 + H2O | Homo sapiens | CXCL-12 is a physiological substrate for secreted cathepsin X | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBR2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | cathepsin X can be secreted by nonhematopoietic bone marrow cells in an activated form | Homo sapiens | - |
bone marrow stromal cell | - |
Homo sapiens | - |
CAL-72 cell | an osteoblastic cell line | Homo sapiens | - |
L87/4 cell | a bone marrow stromal cell line | Homo sapiens | - |
L88/5 cell | a bone marrow stromal cell line | Homo sapiens | - |
additional information | no enzyme secretion from hematopoietic stem and progenitor cells, e.g. CD34+ HSPC, G292 cells | Homo sapiens | - |
osteoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-methoxycoumarin-4-ylacetyl-RPPGFSAFK-N-epsilon-2,4-dinitrophenol + H2O | fluorescence cathepsin X/A-selective substrate | Homo sapiens | ? | - |
? | |
CXCL-12 + H2O | CXCL-12 is a physiological substrate for secreted cathepsin X | Homo sapiens | ? | - |
? | |
CXCL-12 + H2O | chemokine CXCL-12 is a highly potent chemoattractant for HSC secreted by osteoblasts. The exo-peptidase cathepsin X gradually cleaves fifteen amino acids until proline P74 is present at the P2 position | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin Z | - |
Homo sapiens |
mopre | cathepsin X belongs to the CA clan of cysteine peptidases | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | cysteine cathepsin proteases are primarily involved in endolysosomal degradation, but also function extracellularly and in the nucleus. Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells, i.e. HSPC s, to osteoblasts. Cathepsin X can influence HSPC trafficking in the bone marrow | Homo sapiens |