Literature summary for 3.4.18.1 extracted from

Obermajer, N.; Magister, S.; Kopitar, A.N.; Tepes, B.; Ihan, A.; Kos, J.
Cathepsin X prevents an effective immune response against Helicobacter pylori infection (2009), Eur. J. Cell Biol., 88, 461-471.

Search for more literature for 3.4.18.1

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	cathepsin X inhibiting 2F12 mAb	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-
plasma membrane	cathepsin X shows marked co-localization with Mac-1 integrin receptor on the plasma membrane of differentiated THP-1 cells primed with Helicobacter pylori antigen of group A of therapy-resistant strains. Priming with Helicobacter pylori antigen of groupB of therapy-susceptible strains results in less extensive co-localization with Mac-1	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UBR2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	cathepsin X shows marked co-localization with Mac-1 integrin receptor on the plasma membrane of differentiated THP-1 cells primed with Helicobacter pylori antigen of group A of therapy-resistant strains. Priming with Helicobacter pylori antigen of groupB of therapy-susceptible strains results in less extensive co-localization with Mac-1	Homo sapiens	-
THP-1 cell	primary	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	Helicobacter pylori antigens from subjects with gastritis, who are successful in eradicating the infection after antibiotic therapy, decrease the membrane expression of cathepsin X in THP-1 cells	down
Homo sapiens	Helicobacter pylori antigens from subjects with gastritis, who are unsuccessful in eradicating the infection after antibiotic therapy, increase the membrane expression of cathepsin X in THP-1 cells	up

General Information

General Information	Comment	Organism
malfunction	cathepsin X prevents an effective immune response against Helicobacter pylori infection of THP-1 cells, overview	Homo sapiens

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Release 2023.1 (January 2023)