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Literature summary for 3.4.18.1 extracted from

  • Obermajer, N.; Jevnikar, Z.; Doljak, B.; Sadaghiani, A.M.; Bogyo, M.; Kos, J.
    Cathepsin X-mediated beta2 integrin activation results in nanotube outgrowth (2009), Cell. Mol. Life Sci., 66, 1126-1134.
    View publication on PubMed
Search for more literature for 3.4.18.1

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of cathepsin X with either AMS36 or 2F12mAb Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
additional information although cathepsin X is a lysosomal protease, its localization and trafficking is dependent on the state of cell activation, and it is translocated towards the plasma membrane upon leukocyte activation Homo sapiens
-
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin X is an important regulator of LFA-1 activity, and cathepsin X-upregulated Jurkat T cells exhibit increased homotypic aggregation, cathepsin X induces polarized migration-associated morphology in Jurkat T cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBR2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin X is an important regulator of LFA-1 activity, and cathepsin X-upregulated Jurkat T cells exhibit increased homotypic aggregation, cathepsin X induces polarized migration-associated morphology in Jurkat T cells, overview Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function cathepsin X-mediated beta2 integrin activation results in membrane nanotube outgrowth, nanotube structures and mechanism of membrane nanotube formation in T cells through LFA-1 integrin activation by the cysteine protease cathepsin X, mechanism of nanotube formation follows homotypic T cell contact formation,mechanism pf LFA-1 iuntegrin activation, overview Homo sapiens