Literature summary for 3.4.18.1 extracted from

Krueger, S.; Kuester, D.; Bernhardt, A.; Wex, T.; Roessner, A.
Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages (2009), J. Pathol., 217, 581-588.

Search for more literature for 3.4.18.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	CagA, upregulation of CTSX is more intense in tissue samples of patients with CagA+ Helicobacter pylori than in those with CagA- Helicobacter pylori	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the addition of the specific MEK1/2 inhibitor U0126 reduces Helicobacter pylori-stimulated CTSX expression in U937 monocytes, but not in NCI-N87 cells. In NCIN87 cells, the regulation is controlled by p38 and JNK. Inhibition by SB203580 and SP600125 completely abolish the stimulated CTSX protein expression of NCI-N87 cells in response to Helicobacter pylori infection	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients infected with Helicobacter pylori	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	strongly upregulated in infected gastric mucosa and intestinal-type gastric cancer	Homo sapiens	-
NCI-N87 cell	human gastric epithelial cell	Homo sapiens	-
U-937 cell	monocytic	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
cathepsin X	-	Homo sapiens
CTSX	-	Homo sapiens

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Release 2023.1 (January 2023)