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Literature summary for 3.4.18.1 extracted from

  • Wendt, W.; Zhu, X.R.; Luebbert, H.; Stichel, C.C.
    Differential expression of cathepsin X in aging and pathological central nervous system of mice (2007), Exp. Neurol., 204, 525-540.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm somal Homo sapiens 5737
-
cytoplasm somal, enzyme in close proximity to the mitochondria, the rough endoplasmic reticulum, and the nuclear membrane Mus musculus 5737
-
lysosome
-
Homo sapiens 5764
-
lysosome multivesicular bodies and lipofuscin granules Mus musculus 5764
-
additional information subcellular localization, overview Homo sapiens
-
-
additional information subcellular localization in aged and pathological brain tissues, overview, no activity in the extracellular space Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is associated with plaques in Alzheimer patients, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
wild-type C57BL/6 mice, Alzheimer's double disease mice, and amyotrophic lateral sclerosis SOD1-G93A mice
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Mus musculus
-
brain
-
Mus musculus
-
brain the enzyme is associated with plaques in Alzheimer patients, overview Homo sapiens
-
brain stem
-
Mus musculus
-
brain stem
-
Homo sapiens
-
central nervous system healthy, aging, and pathological, expression patterns of cathepsin X, overview Mus musculus
-
cerebellum
-
Mus musculus
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Mus musculus
-
cerebral cortex of healthy individuals and Alzheimer patients Homo sapiens
-
glial cell
-
Homo sapiens
-
glial cell the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis Mus musculus
-
microglia
-
Mus musculus
-
additional information tissue distribution, immunohistochemic analysis, overview Mus musculus
-
additional information tissue distribution, immunohistochemic analysis, overview Homo sapiens
-
neuron
-
Mus musculus
-
oligodendrocyte very low enzyme content Mus musculus
-
spinal cord
-
Mus musculus
-
spinal cord
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is associated with plaques in Alzheimer patients, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cathepsin X
-
Mus musculus
cathepsin X
-
Homo sapiens
CATX
-
Mus musculus
CATX
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5
-
assay at Mus musculus
3.5
-
assay at Homo sapiens