Protein Variants | Comment | Organism |
---|---|---|
additional information | the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | somal | Homo sapiens | 5737 | - |
cytoplasm | somal, enzyme in close proximity to the mitochondria, the rough endoplasmic reticulum, and the nuclear membrane | Mus musculus | 5737 | - |
lysosome | - |
Homo sapiens | 5764 | - |
lysosome | multivesicular bodies and lipofuscin granules | Mus musculus | 5764 | - |
additional information | subcellular localization, overview | Homo sapiens | - |
- |
additional information | subcellular localization in aged and pathological brain tissues, overview, no activity in the extracellular space | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is associated with plaques in Alzheimer patients, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
wild-type C57BL/6 mice, Alzheimer's double disease mice, and amyotrophic lateral sclerosis SOD1-G93A mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
brain | the enzyme is associated with plaques in Alzheimer patients, overview | Homo sapiens | - |
brain stem | - |
Mus musculus | - |
brain stem | - |
Homo sapiens | - |
central nervous system | healthy, aging, and pathological, expression patterns of cathepsin X, overview | Mus musculus | - |
cerebellum | - |
Mus musculus | - |
cerebellum | - |
Homo sapiens | - |
cerebral cortex | - |
Mus musculus | - |
cerebral cortex | of healthy individuals and Alzheimer patients | Homo sapiens | - |
glial cell | - |
Homo sapiens | - |
glial cell | the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis | Mus musculus | - |
microglia | - |
Mus musculus | - |
additional information | tissue distribution, immunohistochemic analysis, overview | Mus musculus | - |
additional information | tissue distribution, immunohistochemic analysis, overview | Homo sapiens | - |
neuron | - |
Mus musculus | - |
oligodendrocyte | very low enzyme content | Mus musculus | - |
spinal cord | - |
Mus musculus | - |
spinal cord | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is associated with plaques in Alzheimer patients, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin X | - |
Mus musculus |
cathepsin X | - |
Homo sapiens |
CATX | - |
Mus musculus |
CATX | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.5 | - |
assay at | Mus musculus |
3.5 | - |
assay at | Homo sapiens |