Literature summary for 3.4.17.8 extracted from

Belhaj, M.; Boutiba-Ben Boubaker, I.; Slim, A.
Penicillin-binding protein 5 sequence alteration and levels of plp5 mRNA expression in clinical isolates of Enterococcus faecium with different levels of ampicillin resistance (2016), Microb. Drug Resist., 22, 202-210 .

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Application

Application	Comment	Organism
medicine	comparison of 82 ampicillin-resistant Enterococcus faecium isolates from clinical infections. Sequence data reveal the existence of 19 different PLP5 alleles with a difference in 16 amino acid positions spanning from residue 414 to 632. Each allele presents at least five amino acid substitutions (His470/Gln, Asn496/Lys, Ala499/Thr, Glu525/Asp, and Glu629/Val). No correlation between amino acid sequence polymorphism of PBP5 and levels of ampicillin resistance is detected. The levels of PLP5 mRNA expression varies between strains and does not always correlate with levels of ampicillin resistance in clinical isolates	Enterococcus faecium

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecium	A0A075Q0W3	-	-

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Release 2023.1 (January 2023)